As there is the upcoming exam coming up, I thought we could all use a little review. So I repurposed Vanilla Ice’s “Ice Ice Baby” to review Dr. Lill’s 45 slide lecture.<\/p>\n
About to start a cascade of mem’rization<\/p>\n
Svensson & Lill both say we gotta know<\/p>\n
The importance here of Pharmacology’s role<\/p>\n
Xenobiotics, toxins attack<\/p>\n
Cytochrome 450 deals with that crap<\/p>\n
Enzymes, conjugating functional groups<\/p>\n
Better solubility, all a part of Phase II<\/p>\n
Glucoronidation, so polar, you’ll see<\/p>\n
Metabolites ending all up in your pee<\/p>\n
And if you’re tamoxifen? Just need a hydroxy.<\/p>\n
Binds like estrogen a hundred fold more tightly<\/p>\n
Bioactivation of a product therapeutic<\/p>\n
if you had breast cancer it’s a way to try to treat it.<\/p>\n
<\/p>\n
[CHORUS] <\/p>\n Packing heme and stuck to a membrane,<\/p>\n Gonna need electrons from your reductase<\/p>\n Aromatic hydroxylation? Can’t wait.<\/p>\n Can also dealkylate, oxidize, deaminate.<\/p>\n Sulfoxidation, what the hell’s that?<\/p>\n Just add a carbonyl, just stuck where the sulfur’s at.<\/p>\n Ketoconazole? Inhibitor that’ll fight<\/p>\n Off other substrates, bumping up their half-life.<\/p>\n Mechanism-based? Whoa, that\u00e2\u20ac\u2122s suicide.<\/p>\n Gonna need that enzyme resynthesized.<\/p>\n Binding moeities, 2C, cimetidine<\/p>\n inhibits not Advil, but raises your warfarin<\/p>\n What the hell?! It’s the same damn enzyme,<\/p>\n But they’re in the active site at the same time!<\/p>\n <\/p>\n [Chorus]<\/strong><\/p>\n <\/p>\n Induction! From this biochem crosstalk<\/p>\n Metabolism gets kicked up another notch<\/p>\n Transcription! for more enzyme production<\/p>\n Common substrates means drug interactions<\/p>\n Metabolite toxicity? I don’t know!<\/p>\n Like P-A-H, gives you cancer down below<\/p>\n So no more cigarettes or char-grilled cattle meat<\/p>\n Hey, you can always just freaking boil it.<\/p>\n <\/p>\n [Chorus]<\/strong><\/p>\n <\/p>\n C-Y-P-3-A-4 does a third of all drugs<\/p>\n but anti-fungal azos leave it stopped up.<\/p>\n When he takes midazolam and alfentanyl,<\/p>\n Upped levels of both mean that his diaphragm is still<\/p>\n Tell the nurse to run and get him a ventilator<\/p>\n and get set to defend yo’self from the prosecutor<\/p>\n Grapefruit, messing with 3A4’s career<\/p>\n It works lopinavir, not so with ritonavir<\/p>\n Mash em up, Kaletra’s got longer action<\/p>\n Just avoid citrus; it’s packing Naringinin<\/p>\n On to Phase II, UGT’s right next door<\/p>\n Adding glucoronide makes things more polar<\/p>\n Doesn’t matter, O or N or S<\/p>\n UGT will add a sugar right onto it.<\/p>\n Don’t forget SULT conjugating glutathione<\/p>\n To catecholamines, phenolics, and the steroid hormones<\/p>\n Let that be it. Please say that’s where it ends.<\/p>\n Whoa, whoa, we still got patient variance! [Chorus] Race, sex, nutrition and location<\/p>\n Personal genetic mutation variation<\/p>\n Environmental stuff may just activate<\/p>\n Enzymes to go ahead & upregulate<\/p>\n Giving chloramphenical to some newborns<\/p>\n Only to find in the morning, their color is all gone.<\/p>\n Whoops, we forgot about their immature UGT<\/p>\n And accidentally dosed them all the way to toxicity<\/p>\n Hypervariable, just look at that graph!<\/p>\n So when you dose, please triple check your math.<\/p>\n With just efflux pumps, the poor kid’s helpless<\/p>\n So please don’t give harsh drugs to the fetuses.<\/p>\n \n <\/p>\n Alcoholic cirrhosis, active chronic hepatitis<\/p>\n Less first pass blood flow, less enzymes going at it<\/p>\n Then there’s the elderly, where everything’s slower<\/p>\n Less blood flowing round and the liver mass is lower<\/p>\n Not to mention probably all the polypharmacy<\/p>\n Making their liver a pharmaceutical potpourri<\/p>\n All the random individual genetic factors,<\/p>\n Makes us poor, or ultrafast metabolizers<\/p>\n Like that mama with the morphine in her breast milk excreting<\/p>\n If only she had started with some formula and bottle feeding.<\/p>\n So take heed from this lyrical poet,<\/p>\n This exam won’t be easy and deep down we all know it.<\/p>\n Now the coffee wears off and we finally get to snooze<\/p>\n Only because the action of CYP 1A2 As there is the upcoming exam coming up, I thought we could all use a little review. So I repurposed Vanilla Ice’s “Ice Ice Baby” to review Dr. Lill’s 45 slide lecture. All right, STOP get out your notes and listen About to start a cascade of mem’rization Svensson & Lill both say we gotta […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/posts\/2431"}],"collection":[{"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2431"}],"version-history":[{"count":7,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/posts\/2431\/revisions"}],"predecessor-version":[{"id":3529,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=\/wp\/v2\/posts\/2431\/revisions\/3529"}],"wp:attachment":[{"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2431"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2431"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tommy.lardbucket.org\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2431"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nP-Four-Fifty, Cytochrome P-four-fifty(x4)<\/strong><\/p>\n
\n<\/p>\n
\n<\/strong>
\n <\/p>\n
\n[Chorus]<\/strong><\/p>\n
\n
\n[Chorus]<\/strong><\/div>\n","protected":false},"excerpt":{"rendered":"